Find Copa Airlines flights from Medellin (MDE) to Guayaquil (GYE) from COP 1.386.160*
expand_more
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Restrictions apply; please see Terms & Conditions.
Best prices on Medellin to Guayaquil flights
location_on
location_on
Best airfares from Medellin to Guayaquil flights
flight_takeoff
flight_land
COP
From | To | Fare Type | Dates | Price |
|---|---|---|---|---|
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jun 18, 2026 - Jun 20, 2026 | From COPÂ 1.386.160 Viewed 17 minutes ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jun 18, 2026 - Jun 23, 2026 | From COPÂ 1.391.262 Viewed 15 minutes ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jun 15, 2026 - Jun 20, 2026 | From COPÂ 1.422.442 Viewed 17 minutes ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | May 11, 2026 - May 14, 2026 | From COPÂ 1.376.758 Viewed 1 day ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | May 15, 2026 - May 19, 2026 | From COPÂ 1.376.758 Viewed 23 hours ago |
*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.
Find more related flights
Our App
Download the Copa Airlines App now and buy tickets, manage your reservations, access to your ConnectMiles account and much more.

Subscribe and save!
Subscribe and be one of the first to know about our exclusive fares, promotions and last minute offers.
Subscribe