What is the best fare to fly from Santa Cruz?

The best fare to fly from Santa Cruz starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santa Cruz (VVI) from USD563*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Santa Cruz

From

Budget

USD

Santa Cruz (VVI)to

Cartagena (CTG)

Sep 07, 2026 - Sep 12, 2026

From

USD565

Viewed 5 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Bogota (BOG)

Apr 30, 2026 - May 04, 2026

From

USD572

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Cancun (CUN)

May 02, 2026 - May 06, 2026

From

USD597

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Panama (PTY)

Apr 10, 2026 - Apr 18, 2026

From

USD621

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Punta Cana (PUJ)

May 02, 2026 - May 09, 2026

From

USD632

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Mexico City (MEX)

May 19, 2026 - May 22, 2026

From

USD649

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Miami (MIA)

Oct 26, 2026 - Nov 04, 2026

From

USD688

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

New York (JFK)

Apr 27, 2026 - May 03, 2026

From

USD765

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Caracas (CCS)

Apr 18, 2026 - May 18, 2026

From

USD792

Viewed 5 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Washington Dulles (IAD)

Apr 28, 2026 - May 07, 2026

From

USD800

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Orlando (MCO)

Apr 24, 2026 - May 17, 2026

From

USD851

Viewed 21 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Boston (BOS)

Apr 21, 2026 - Apr 28, 2026

From

USD863

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santa Cruz flights

From

Budget

USD

Santa Cruz (VVI)to

Cancun (CUN)

May 02, 2026 - May 06, 2026

Round trip

Economy

From

USD597

Viewed 1 day ago

Santa Cruz (VVI)to

Panama (PTY)

Apr 18, 2026 - Apr 25, 2026

Round trip

Economy

From

USD621

Viewed 1 day ago

Santa Cruz (VVI)to

Mexico City (MEX)

May 19, 2026 - May 22, 2026

Round trip

Economy

From

USD649

Viewed 1 day ago

Santa Cruz (VVI)to

Miami (MIA)

May 09, 2026 - May 16, 2026

Round trip

Economy

From

USD688

Viewed 1 day ago

Santa Cruz (VVI)to

New York (JFK)

May 13, 2026 - May 24, 2026

Round trip

Economy

From

USD765

Viewed 19 hours ago

Santa Cruz (VVI)to

Washington Dulles (IAD)

May 04, 2026 - May 25, 2026

Round trip

Economy

From

USD800

Viewed 21 hours ago

Flights from Santa Cruz with Copa Airlines

Through its Hub of the Americas, Copa Airlines offers flights from Santa Cruz to more than 60 destinations in the Americas. In addition, your ability to manage the details of your booking online will allow you to enjoy a first-class experience from the moment your purchase your ticket.

Departing from the international airport of Santa Cruz

Viru Viru International Airport (VVI) is located 13 km north of the city centre. The cheapest way to get there is to take a shuttle from the center of the city. The shuttles operate from 5 AM to 8 PM and have space for luggage. Depending on your flight schedule, it is likely that you will need to take a taxi, which are available 24 hours. The airport has several restaurants and coffee shops so that you can relax before boarding. You can also take advantage of the time to shop at the duty-free store.

Travel from Santa Cruz with Copa Airlines

Copa Airlines has one of the newest fleets in the region and provides numerous options for entertainment, movies and music so that your flight from Santa Cruz will be enjoyable. Book your ticket today!