What is the best fare to fly from Santa Cruz?

The best fare to fly from Santa Cruz starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santa Cruz (VVI) from USD 728*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Santa Cruz

From

Budget

USD

Santa Cruz (VVI)to

Cartagena (CTG)

Aug 25, 2026 - Sep 02, 2026

From

USD 588

Viewed 17 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Bogota (BOG)

Sep 04, 2026 - Sep 11, 2026

From

USD 607

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Miami (MIA)

May 11, 2026 - Jun 14, 2026

From

USD 638

Viewed 21 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Havana (HAV)

Jun 11, 2026 - Jun 26, 2026

From

USD 676

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Fort Lauderdale (FLL)

May 11, 2026 - Jun 14, 2026

From

USD 677

Viewed 21 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Mexico City (MEX)

May 08, 2026 - May 13, 2026

From

USD 706

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Panama (PTY)

Aug 10, 2026 - Aug 16, 2026

From

USD 728

Viewed 17 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Cancun (CUN)

Dec 23, 2026 - Dec 28, 2026

From

USD 758

Viewed 16 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Punta Cana (PUJ)

Aug 20, 2026 - Aug 29, 2026

From

USD 792

Viewed 11 hours ago

Round trip

Economy

Santa Cruz (VVI)to

New York (JFK)

Aug 07, 2026 - Aug 17, 2026

From

USD 874

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Santo Domingo (SDQ)

Sep 16, 2026 - Oct 05, 2026

From

USD 877

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Chicago (ORD)

Oct 01, 2026 - Oct 09, 2026

From

USD 886

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santa Cruz flights

From

Budget

USD

Santa Cruz (VVI)to

Miami (MIA)

Jun 03, 2026 - Jun 14, 2026

Round trip

Economy

From

USD 638

Viewed 16 hours ago

Santa Cruz (VVI)to

Havana (HAV)

Sep 08, 2026 - Sep 17, 2026

Round trip

Economy

From

USD 676

Viewed 1 day ago

Santa Cruz (VVI)to

Mexico City (MEX)

Aug 04, 2026 - Aug 27, 2026

Round trip

Economy

From

USD 706

Viewed 1 day ago

Santa Cruz (VVI)to

Panama (PTY)

Aug 10, 2026 - Aug 16, 2026

Round trip

Economy

From

USD 728

Viewed 17 hours ago

Santa Cruz (VVI)to

Cancun (CUN)

Jun 02, 2026 - Jun 08, 2026

Round trip

Economy

From

USD 758

Viewed 12 hours ago

Santa Cruz (VVI)to

New York (JFK)

Jul 30, 2026 - Aug 31, 2026

Round trip

Economy

From

USD 874

Viewed 19 hours ago

Flights from Santa Cruz with Copa Airlines

Through its Hub of the Americas, Copa Airlines offers flights from Santa Cruz to more than 60 destinations in the Americas. In addition, your ability to manage the details of your booking online will allow you to enjoy a first-class experience from the moment your purchase your ticket.

Departing from the international airport of Santa Cruz

Viru Viru International Airport (VVI) is located 13 km north of the city centre. The cheapest way to get there is to take a shuttle from the center of the city. The shuttles operate from 5 AM to 8 PM and have space for luggage. Depending on your flight schedule, it is likely that you will need to take a taxi, which are available 24 hours. The airport has several restaurants and coffee shops so that you can relax before boarding. You can also take advantage of the time to shop at the duty-free store.

Travel from Santa Cruz with Copa Airlines

Copa Airlines has one of the newest fleets in the region and provides numerous options for entertainment, movies and music so that your flight from Santa Cruz will be enjoyable. Book your ticket today!