Find Copa Airlines flights to Santa Cruz (VVI) from USD390*

Promo Code

Restrictions apply; please see Terms & Conditions.

Fares for flights to Santa Cruz through the Hub of the Americas®,in Panama City

USD

Washington Dulles (IAD)to

Santa Cruz (VVI)
Nov 12, 2025 - Nov 26, 2025
From
USD587
Viewed 1 day ago
Round trip
Economy

Mexico City (MEX)to

Santa Cruz (VVI)
Nov 22, 2025 - Nov 29, 2025
From
USD528
Viewed 23 hours ago
Round trip
Economy

Miami (MIA)to

Santa Cruz (VVI)
Nov 17, 2025 - Dec 18, 2025
From
USD440
Viewed 23 hours ago
Round trip
Economy

Panama (PTY)to

Santa Cruz (VVI)
Apr 10, 2026 - Apr 17, 2026
From
USD512
Viewed 1 day ago
Round trip
Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Plan your next trip to Santa Cruz with these low fares

USD

Washington Dulles (IAD)to

Santa Cruz (VVI)
Jan 01, 2026 - Jan 27, 2026

Round trip

Economy

From
USD587
Viewed 1 day ago

Mexico City (MEX)to

Santa Cruz (VVI)
Feb 18, 2026 - Feb 28, 2026

Round trip

Economy

From
USD561
Viewed 1 day ago

Miami (MIA)to

Santa Cruz (VVI)
Apr 02, 2026 - Apr 07, 2026

Round trip

Economy

From
USD440
Viewed 6 hours ago

Panama (PTY)to

Santa Cruz (VVI)
Feb 15, 2026 - Feb 22, 2026

Round trip

Economy

From
USD512
Viewed 1 day ago

New York (JFK)to

Santa Cruz (VVI)
May 11, 2026 - Jun 02, 2026

Round trip

Economy

From
USD586
Viewed 17 hours ago

Los Angeles (LAX)to

Santa Cruz (VVI)
Jan 21, 2026 - Feb 25, 2026

Round trip

Economy

From
USD657
Viewed 1 day ago

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Fly to Santa Cruz with Copa Air

Santa Cruz receives a third of Bolivia's tourists, attracted by its cultural capital and its entertainment and relaxation activities. Copa Airlines offers flights to Santa Cruz from different parts of the Americas.

What to visit in Santa Cruz?

  • Colonial footprints: the Plaza 24 de Septiembre, located in the city center, is surrounded by buildings dating back to the colonial era, such as the Metropolitan Cathedral, City Hall, and the Cultural Center.
  • Outings in the fresh air: surrounding the city are numerous nature reserves where you can discover the local flora and fauna, participate in outdoor actives, and relax. The most popular are Las Lomas de Arena Regional Park, the Güembé Biocenter, and the Ivaga Guazú Ecological Park.
  • Go shopping: Santa Cruz boasts malls and shops with domestic and imported items, where you can buy a variety of products and gifts.

Getting around Santa Cruz

The simplest way of touring the city is to use some of the 132 urban bus routes. You can also rent a car or take a taxi to reach more remote destinations. Thanks to the excellent service aboard Copa Airlines, your flight to Santa Cruz will be a very pleasant experience. Book your flight today.