Find Copa Airlines flights from Mexico from USD291*

Offers on flights from Mexico

From

Budget

USD

Mexico City (MEX)to

Panama (PTY)

May 13, 2026 - May 17, 2026

From

USD291

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Lima (LIM)

Apr 02, 2026 - Apr 03, 2026

From

USD345

Viewed 3 hours ago

Round trip

Economy

Cancun (CUN)to

Panama (PTY)

Sep 30, 2026 - Oct 05, 2026

From

USD351

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Bogota (BOG)

Apr 12, 2026 - Apr 16, 2026

From

USD411

Viewed 5 hours ago

Round trip

Economy

Guadalajara (GDL)to

Medellin (MDE)

Nov 16, 2026 - Nov 25, 2026

From

USD453

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Punta Cana (PUJ)

Aug 21, 2026 - Aug 26, 2026

From

USD455

Viewed 16 hours ago

Round trip

Economy

Mexico City (MEX)to

Medellin (MDE)

Apr 10, 2026 - May 08, 2026

From

USD464

Viewed 2 minutes ago

Round trip

Economy

Guadalajara (GDL)to

Panama (PTY)

May 14, 2026 - May 23, 2026

From

USD540

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Buenos Aires (EZE)

Apr 04, 2026 - Apr 28, 2026

From

USD623

Viewed 32 minutes ago

Round trip

Economy

Mexico City (MEX)to

Rio de Janeiro (GIG)

Jun 16, 2026 - Jun 26, 2026

From

USD649

Viewed 18 hours ago

Round trip

Economy

Mexico City (MEX)to

Caracas (CCS)

Apr 22, 2026 - Apr 27, 2026

From

USD660

Viewed 20 hours ago

Round trip

Economy

Mexico City (MEX)to

Santiago de Chile (SCL)

Oct 09, 2026 - Oct 17, 2026

From

USD744

Viewed 19 hours ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Lowest fares from Mexico

From

Budget

USD

Mexico City (MEX)to

Panama (PTY)

May 13, 2026 - May 17, 2026

Round trip

Economy

From

USD291

Viewed 1 day ago

Mexico City (MEX)to

Punta Cana (PUJ)

Aug 21, 2026 - Aug 26, 2026

Round trip

Economy

From

USD455

Viewed 16 hours ago

Mexico City (MEX)to

Medellin (MDE)

Aug 12, 2026 - Aug 19, 2026

Round trip

Economy

From

USD499

Viewed 19 hours ago

Mexico City (MEX)to

Rio de Janeiro (GIG)

Jun 16, 2026 - Jun 26, 2026

Round trip

Economy

From

USD649

Viewed 18 hours ago

Mexico City (MEX)to

Caracas (CCS)

May 08, 2026 - May 18, 2026

Round trip

Economy

From

USD661

Viewed 9 hours ago

Mexico City (MEX)to

Buenos Aires (EZE)

May 10, 2026 - May 22, 2026

Round trip

Economy

From

USD671

Viewed 20 hours ago

Travel from Mexico

Traveling from Mexico

From Mexico, you can go anywhere on the continent when you travel through the Hub of the Americas® in Panama with Copa Airlines. Whether you’re traveling from Cancun, Mexico City, Guadalajara, Monterrey, or Puerto Vallarta, Copa Airlines connects you to a growing number of destinations in more than 30 countries across the Americas.

Book your travel at copa.com for a worry-free experience. You’ll be able to manage all your travel details in one place. Purchase your ticket, rent a car, buy travel insurance, or arrange ground transportation. Have you heard about our frequent flyer program yet? To earn valuable miles for every trip, join ConnectMiles free of charge and learn about all the benefits it offers.