What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD 583*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Jun 15, 2026 - Jul 14, 2026

From

USD 288

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Jun 12, 2026 - Jun 21, 2026

From

USD 293

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Oct 11, 2026 - Oct 15, 2026

From

USD 297

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Guatemala (GUA)

Jul 02, 2026 - Jul 09, 2026

From

USD 322

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

Jun 24, 2026 - Jul 04, 2026

From

USD 323

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Nov 20, 2026 - Nov 25, 2026

From

USD 354

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Mexico City (MEX)

Jun 17, 2026 - Jun 26, 2026

From

USD 460

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Jul 14, 2026 - Jul 21, 2026

From

USD 583

Viewed 18 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Jun 27, 2026 - Jul 01, 2026

From

USD 637

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

Sep 22, 2026 - Oct 08, 2026

From

USD 666

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Jun 24, 2026 - Jun 28, 2026

From

USD 815

Viewed 16 minutes ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Jul 09, 2026 - Sep 21, 2026

From

USD 836

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Oct 14, 2026 - Oct 20, 2026

Round trip

Economy

From

USD 288

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Sep 08, 2026 - Sep 11, 2026

Round trip

Economy

From

USD 293

Viewed 1 day ago

Santo Domingo (SDQ)to

Guatemala (GUA)

Aug 10, 2026 - Aug 24, 2026

Round trip

Economy

From

USD 322

Viewed 1 day ago

Santo Domingo (SDQ)to

Lima (LIM)

Aug 24, 2026 - Aug 28, 2026

Round trip

Economy

From

USD 354

Viewed 1 day ago

Santo Domingo (SDQ)to

Panama (PTY)

Jul 22, 2026 - Jul 26, 2026

Round trip

Economy

From

USD 583

Viewed 38 minutes ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Oct 22, 2026 - Oct 28, 2026

Round trip

Economy

From

USD 836

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.