What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD288*

1 Passenger

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Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

May 11, 2026 - May 15, 2026

From

USD288

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Aug 19, 2026 - Aug 24, 2026

From

USD293

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Jul 26, 2026 - Jul 31, 2026

From

USD297

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Jul 15, 2026 - Jul 29, 2026

From

USD314

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

Jun 03, 2026 - Jun 06, 2026

From

USD323

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Mexico City (MEX)

Apr 29, 2026 - May 03, 2026

From

USD414

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Quito (UIO)

Jun 01, 2026 - Jun 07, 2026

From

USD443

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Apr 08, 2026 - Apr 10, 2026

From

USD531

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Oct 27, 2026 - Nov 02, 2026

From

USD572

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

Jun 04, 2026 - Jun 14, 2026

From

USD720

Viewed 12 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Oct 25, 2026 - Oct 30, 2026

From

USD779

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

May 18, 2026 - May 24, 2026

From

USD825

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

May 05, 2026 - May 09, 2026

Round trip

Economy

From

USD288

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Aug 19, 2026 - Aug 24, 2026

Round trip

Economy

From

USD293

Viewed 1 day ago

Santo Domingo (SDQ)to

Lima (LIM)

Jul 13, 2026 - Jul 22, 2026

Round trip

Economy

From

USD314

Viewed 1 day ago

Santo Domingo (SDQ)to

Panama (PTY)

Jul 03, 2026 - Jul 13, 2026

Round trip

Economy

From

USD607

Viewed 1 day ago

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Jun 09, 2026 - Jun 20, 2026

Round trip

Economy

From

USD803

Viewed 1 day ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Aug 14, 2026 - Aug 25, 2026

Round trip

Economy

From

USD825

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.