What is the best fare to fly from Santa Cruz?

The best fare to fly from Santa Cruz starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santa Cruz (VVI) from USD505*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Santa Cruz

From

Budget

USD

Santa Cruz (VVI)to

Miami (MIA)

May 19, 2026 - May 29, 2026

From

USD539

Viewed 20 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Mexico City (MEX)

May 19, 2026 - May 29, 2026

From

USD545

Viewed 19 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Cancun (CUN)

May 09, 2026 - May 16, 2026

From

USD572

Viewed 16 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Havana (HAV)

May 07, 2026 - May 11, 2026

From

USD664

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Panama (PTY)

May 19, 2026 - May 23, 2026

From

USD669

Viewed 14 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Fort Lauderdale (FLL)

Apr 07, 2026 - Apr 15, 2026

From

USD677

Viewed 3 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Quito (UIO)

Apr 30, 2026 - May 05, 2026

From

USD749

Viewed 17 hours ago

Round trip

Economy

Santa Cruz (VVI)to

Raleigh (RDU)

May 22, 2026 - Jun 12, 2026

From

USD831

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

New York (JFK)

Aug 06, 2026 - Aug 14, 2026

From

USD874

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Chicago (ORD)

Aug 06, 2026 - Aug 19, 2026

From

USD886

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Punta Cana (PUJ)

May 05, 2026 - May 10, 2026

From

USD893

Viewed 1 day ago

Round trip

Economy

Santa Cruz (VVI)to

Orlando (MCO)

Jan 23, 2027 - Feb 01, 2027

From

USD897

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santa Cruz flights

From

Budget

USD

Santa Cruz (VVI)to

Miami (MIA)

May 05, 2026 - May 17, 2026

Round trip

Economy

From

USD539

Viewed 1 day ago

Santa Cruz (VVI)to

Mexico City (MEX)

May 02, 2026 - May 16, 2026

Round trip

Economy

From

USD545

Viewed 23 hours ago

Santa Cruz (VVI)to

Cancun (CUN)

May 09, 2026 - May 16, 2026

Round trip

Economy

From

USD572

Viewed 16 hours ago

Santa Cruz (VVI)to

Panama (PTY)

May 19, 2026 - May 23, 2026

Round trip

Economy

From

USD669

Viewed 14 hours ago

Santa Cruz (VVI)to

New York (JFK)

Sep 22, 2026 - Sep 28, 2026

Round trip

Economy

From

USD874

Viewed 22 hours ago

Santa Cruz (VVI)to

Punta Cana (PUJ)

May 05, 2026 - May 10, 2026

Round trip

Economy

From

USD893

Viewed 1 day ago

Flights from Santa Cruz with Copa Airlines

Through its Hub of the Americas, Copa Airlines offers flights from Santa Cruz to more than 60 destinations in the Americas. In addition, your ability to manage the details of your booking online will allow you to enjoy a first-class experience from the moment your purchase your ticket.

Departing from the international airport of Santa Cruz

Viru Viru International Airport (VVI) is located 13 km north of the city centre. The cheapest way to get there is to take a shuttle from the center of the city. The shuttles operate from 5 AM to 8 PM and have space for luggage. Depending on your flight schedule, it is likely that you will need to take a taxi, which are available 24 hours. The airport has several restaurants and coffee shops so that you can relax before boarding. You can also take advantage of the time to shop at the duty-free store.

Travel from Santa Cruz with Copa Airlines

Copa Airlines has one of the newest fleets in the region and provides numerous options for entertainment, movies and music so that your flight from Santa Cruz will be enjoyable. Book your ticket today!