What is the best fare to fly from Chicago?

The best fare to fly from Chicago starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Chicago (ORD) from USD305*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Chicago

From

Budget

USD

Chicago (ORD)to

Bogota (BOG)

Jul 29, 2026 - Aug 01, 2026

From

USD305

Viewed 15 hours ago

Round trip

Economy

Chicago (ORD)to

Guatemala (GUA)

Jan 20, 2027 - Jan 30, 2027

From

USD321

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Cartagena (CTG)

Apr 24, 2026 - Apr 28, 2026

From

USD333

Viewed 18 hours ago

Round trip

Economy

Chicago (ORD)to

Cali (CLO)

Apr 17, 2026 - Apr 20, 2026

From

USD375

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Medellin (MDE)

Apr 09, 2026 - Apr 15, 2026

From

USD381

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Lima (LIM)

Apr 25, 2026 - May 04, 2026

From

USD408

Viewed 2 hours ago

Round trip

Economy

Chicago (ORD)to

Quito (UIO)

Apr 18, 2026 - May 02, 2026

From

USD422

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Guayaquil (GYE)

Oct 02, 2026 - Oct 06, 2026

From

USD428

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

San José (SJO)

Apr 21, 2026 - Apr 24, 2026

From

USD470

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Rio de Janeiro (GIG)

Jul 12, 2026 - Aug 01, 2026

From

USD610

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Panama (PTY)

Jan 23, 2027 - Feb 01, 2027

From

USD627

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Sao Paulo (GRU)

Mar 18, 2026 - Mar 22, 2026

From

USD768

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Chicago flights

From

Budget

USD

Chicago (ORD)to

Medellin (MDE)

Apr 16, 2026 - Apr 20, 2026

Round trip

Economy

From

USD381

Viewed 1 day ago

Chicago (ORD)to

Lima (LIM)

Apr 25, 2026 - May 16, 2026

Round trip

Economy

From

USD408

Viewed 2 hours ago

Chicago (ORD)to

Quito (UIO)

Apr 18, 2026 - May 02, 2026

Round trip

Economy

From

USD422

Viewed 1 day ago

Chicago (ORD)to

Guayaquil (GYE)

May 10, 2026 - May 23, 2026

Round trip

Economy

From

USD428

Viewed 1 day ago

Chicago (ORD)to

Panama (PTY)

Aug 10, 2026 - Aug 15, 2026

Round trip

Economy

From

USD627

Viewed 1 day ago

Chicago (ORD)to

Sao Paulo (GRU)

Jun 10, 2026 - Sep 01, 2026

Round trip

Economy

From

USD849

Viewed 1 day ago

Flights from Chicago with Copa Airlines

When flying from Chicago, Copa Airlines is the best option. Copa airlines offers you a practical and simple way to enjoy your trip without worrying about the little things. Enter the site and manage your flight details, book hotels, and rent cars.

Leaving Chicago’s International Airport

Chicago O'Hare International Airport (ORD) is located 27 km northwest of the center of the city, where it is easily connected to the 24-hour blue line train. For more convenience, you can take a taxi or hire a private shuttle. We offer free Wi-Fi for the first 20 minutes and charging terminals for electronic devices, so you will always be connected. You can also entertain yourself while waiting for your flight by visiting the variety of shops, restaurants, and art exhibitions.

Flying from Chicago with Copa Airlines

Book your flight from Chicago with Copa Airlines and connect to a growing number of destinations across the continent, enjoying a comfortable, timely and safe journey.