Find Copa Airlines flights from Mexico from USD301*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Mexico

From

Budget

USD

Mexico City (MEX)to

Panama (PTY)

Apr 16, 2026 - Apr 25, 2026

From

USD366

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Caracas (CCS)

Apr 29, 2026 - May 09, 2026

From

USD620

Viewed 14 hours ago

Round trip

Economy

Mexico City (MEX)to

Rio de Janeiro (GIG)

Mar 19, 2026 - Mar 24, 2026

From

USD617

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Medellin (MDE)

Mar 10, 2026 - Mar 17, 2026

From

USD385

Viewed 2 hours ago

Round trip

Economy

Mexico City (MEX)to

Punta Cana (PUJ)

Oct 09, 2026 - Oct 14, 2026

From

USD391

Viewed 1 day ago

Round trip

Economy

Cancun (CUN)to

Panama (PTY)

Mar 09, 2026 - Mar 13, 2026

From

USD328

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Lima (LIM)

May 12, 2026 - May 21, 2026

From

USD330

Viewed 1 day ago

Round trip

Economy

Guadalajara (GDL)to

Medellin (MDE)

May 08, 2026 - May 13, 2026

From

USD451

Viewed 12 hours ago

Round trip

Economy

Cancun (CUN)to

Buenos Aires (EZE)

Mar 18, 2026 - Mar 22, 2026

From

USD613

Viewed 4 hours ago

Round trip

Economy

Mexico City (MEX)to

Santiago de Chile (SCL)

Mar 17, 2026 - Mar 30, 2026

From

USD565

Viewed 1 day ago

Round trip

Economy

Mexico City (MEX)to

Buenos Aires (EZE)

Apr 16, 2026 - Apr 30, 2026

From

USD787

Viewed 1 day ago

Round trip

Economy

Guadalajara (GDL)to

Panama (PTY)

Mar 15, 2026 - Mar 20, 2026

From

USD497

Viewed 16 hours ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Lowest fares from Mexico

From

Budget

USD

Mexico City (MEX)to

Panama (PTY)

Apr 15, 2026 - Apr 29, 2026

Round trip

Economy

From

USD366

Viewed 1 day ago

Mexico City (MEX)to

Caracas (CCS)

Apr 29, 2026 - May 09, 2026

Round trip

Economy

From

USD620

Viewed 14 hours ago

Mexico City (MEX)to

Medellin (MDE)

Jul 02, 2026 - Jul 12, 2026

Round trip

Economy

From

USD406

Viewed 1 day ago

Mexico City (MEX)to

Rio de Janeiro (GIG)

May 08, 2026 - May 15, 2026

Round trip

Economy

From

USD617

Viewed 1 day ago

Mexico City (MEX)to

Punta Cana (PUJ)

Apr 18, 2026 - Apr 28, 2026

Round trip

Economy

From

USD480

Viewed 1 day ago

Cancun (CUN)to

Panama (PTY)

May 18, 2026 - May 24, 2026

Round trip

Economy

From

USD328

Viewed 1 day ago

Travel from Mexico

Traveling from Mexico

From Mexico, you can go anywhere on the continent when you travel through the Hub of the Americas® in Panama with Copa Airlines. Whether you’re traveling from Cancun, Mexico City, Guadalajara, Monterrey, or Puerto Vallarta, Copa Airlines connects you to a growing number of destinations in more than 30 countries across the Americas.

Book your travel at copa.com for a worry-free experience. You’ll be able to manage all your travel details in one place. Purchase your ticket, rent a car, buy travel insurance, or arrange ground transportation. Have you heard about our frequent flyer program yet? To earn valuable miles for every trip, join ConnectMiles free of charge and learn about all the benefits it offers.