What is the best fare to fly from Chicago?

The best fare to fly from Chicago starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Chicago (ORD) from USD261*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Chicago

From

Budget

USD

Chicago (ORD)to

Panama (PTY)

Nov 20, 2025 - Nov 23, 2025

From

USD451

Viewed 1 day ago

Round trip
/
Economy

Chicago (ORD)to

Guayaquil (GYE)

Oct 27, 2025 - Nov 05, 2025

From

USD324

Viewed 21 hours ago

Round trip
/
Economy

Chicago (ORD)to

Quito (UIO)

Oct 28, 2025 - Nov 12, 2025

From

USD354

Viewed 14 hours ago

Round trip
/
Economy

Chicago (ORD)to

Bogota (BOG)

Oct 26, 2025 - Oct 29, 2025

From

USD284

Viewed 1 day ago

Round trip
/
Economy

Chicago (ORD)to

Lima (LIM)

Jan 01, 2026 - Feb 18, 2026

From

USD423

Viewed 19 hours ago

Round trip
/
Economy

Chicago (ORD)to

Medellin (MDE)

Oct 20, 2025 - Oct 22, 2025

From

USD357

Viewed 3 hours ago

Round trip
/
Economy

Chicago (ORD)to

Cali (CLO)

Oct 05, 2025 - Oct 17, 2025

From

USD282

Viewed 15 hours ago

Round trip
/
Economy

Chicago (ORD)to

Cartagena (CTG)

Dec 08, 2025 - Dec 15, 2025

From

USD290

Viewed 1 day ago

Round trip
/
Economy

Chicago (ORD)to

Sao Paulo (GRU)

Nov 14, 2025 - Nov 17, 2025

From

USD388

Viewed 7 hours ago

Round trip
/
Economy

Chicago (ORD)to

Rio de Janeiro (GIG)

Oct 07, 2025 - Oct 13, 2025

From

USD404

Viewed 1 day ago

Round trip
/
Economy

Chicago (ORD)to

Santa Cruz (VVI)

Oct 25, 2025 - Oct 31, 2025

From

USD417

Viewed 1 day ago

Round trip
/
Economy

Chicago (ORD)to

Buenos Aires (EZE)

Sep 23, 2025 - Oct 05, 2025

From

USD748

Viewed 1 day ago

Round trip
/
Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Chicago flights

From

Budget

USD

Chicago (ORD)to
Panama (PTY)
Nov 20, 2025 - Nov 23, 2025
Round trip
/
Economy

From
USD451*
Viewed 1 day ago

Chicago (ORD)to
Guayaquil (GYE)
Jan 19, 2026 - Jan 26, 2026
Round trip
/
Economy

From
USD324*
Viewed 1 hour ago

Chicago (ORD)to
Quito (UIO)
Oct 28, 2025 - Nov 12, 2025
Round trip
/
Economy

From
USD354*
Viewed 14 hours ago

Chicago (ORD)to
Bogota (BOG)
Nov 11, 2025 - Nov 21, 2025
Round trip
/
Economy

From
USD284*
Viewed 1 day ago

Chicago (ORD)to
Lima (LIM)
Jan 29, 2026 - Feb 09, 2026
Round trip
/
Economy

From
USD423*
Viewed 1 day ago

Chicago (ORD)to
Medellin (MDE)
Oct 20, 2025 - Oct 22, 2025
Round trip
/
Economy

From
USD357*
Viewed 3 hours ago

Flights from Chicago with Copa Airlines

When flying from Chicago, Copa Airlines is the best option. Copa airlines offers you a practical and simple way to enjoy your trip without worrying about the little things. Enter the site and manage your flight details, book hotels, and rent cars.

Leaving Chicago’s International Airport

Chicago O'Hare International Airport (ORD) is located 27 km northwest of the center of the city, where it is easily connected to the 24-hour blue line train. For more convenience, you can take a taxi or hire a private shuttle. We offer free Wi-Fi for the first 20 minutes and charging terminals for electronic devices, so you will always be connected. You can also entertain yourself while waiting for your flight by visiting the variety of shops, restaurants, and art exhibitions.

Flying from Chicago with Copa Airlines

Book your flight from Chicago with Copa Airlines and connect to a growing number of destinations across the continent, enjoying a comfortable, timely and safe journey.