What is the best fare to fly from Chicago?

The best fare to fly from Chicago starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Chicago (ORD) from USD305*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Chicago

From

Budget

USD

Chicago (ORD)to

Bogota (BOG)

Mar 30, 2026 - Apr 16, 2026

From

USD305

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Guatemala (GUA)

Mar 16, 2026 - Mar 17, 2026

From

USD321

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Cartagena (CTG)

Apr 12, 2026 - Apr 14, 2026

From

USD333

Viewed 21 hours ago

Round trip

Economy

Chicago (ORD)to

Cali (CLO)

Apr 17, 2026 - Apr 30, 2026

From

USD375

Viewed 19 hours ago

Round trip

Economy

Chicago (ORD)to

Medellin (MDE)

Apr 30, 2026 - May 14, 2026

From

USD381

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Quito (UIO)

Apr 03, 2026 - Apr 08, 2026

From

USD422

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Guayaquil (GYE)

Aug 07, 2026 - Aug 31, 2026

From

USD428

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

San José (SJO)

Aug 23, 2026 - Aug 29, 2026

From

USD470

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Lima (LIM)

Apr 30, 2026 - May 10, 2026

From

USD559

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Rio de Janeiro (GIG)

Apr 17, 2026 - Apr 30, 2026

From

USD610

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Panama (PTY)

Jan 20, 2027 - Jan 27, 2027

From

USD627

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Sao Paulo (GRU)

May 12, 2026 - May 27, 2026

From

USD748

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Chicago flights

From

Budget

USD

Chicago (ORD)to

Medellin (MDE)

Apr 20, 2026 - May 14, 2026

Round trip

Economy

From

USD381

Viewed 1 day ago

Chicago (ORD)to

Quito (UIO)

Apr 20, 2026 - May 04, 2026

Round trip

Economy

From

USD422

Viewed 1 day ago

Chicago (ORD)to

Guayaquil (GYE)

Jul 16, 2026 - Aug 03, 2026

Round trip

Economy

From

USD428

Viewed 6 hours ago

Chicago (ORD)to

Lima (LIM)

May 19, 2026 - May 25, 2026

Round trip

Economy

From

USD559

Viewed 1 day ago

Chicago (ORD)to

Panama (PTY)

Jul 19, 2026 - Jul 29, 2026

Round trip

Economy

From

USD627

Viewed 1 day ago

Chicago (ORD)to

Sao Paulo (GRU)

May 12, 2026 - May 27, 2026

Round trip

Economy

From

USD748

Viewed 1 day ago

Flights from Chicago with Copa Airlines

When flying from Chicago, Copa Airlines is the best option. Copa airlines offers you a practical and simple way to enjoy your trip without worrying about the little things. Enter the site and manage your flight details, book hotels, and rent cars.

Leaving Chicago’s International Airport

Chicago O'Hare International Airport (ORD) is located 27 km northwest of the center of the city, where it is easily connected to the 24-hour blue line train. For more convenience, you can take a taxi or hire a private shuttle. We offer free Wi-Fi for the first 20 minutes and charging terminals for electronic devices, so you will always be connected. You can also entertain yourself while waiting for your flight by visiting the variety of shops, restaurants, and art exhibitions.

Flying from Chicago with Copa Airlines

Book your flight from Chicago with Copa Airlines and connect to a growing number of destinations across the continent, enjoying a comfortable, timely and safe journey.