What is the best fare to fly from Chicago?

The best fare to fly from Chicago starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Chicago (ORD) from USD265*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Chicago

From

Budget

USD

Chicago (ORD)to

Panama (PTY)

May 22, 2026 - May 25, 2026

From

USD557

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Quito (UIO)

Feb 15, 2026 - Feb 24, 2026

From

USD355

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Guayaquil (GYE)

Feb 06, 2026 - Feb 16, 2026

From

USD342

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Lima (LIM)

Mar 04, 2026 - Mar 19, 2026

From

USD497

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

San José (SJO)

Feb 24, 2026 - Mar 03, 2026

From

USD303

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Medellin (MDE)

Mar 05, 2026 - Mar 08, 2026

From

USD300

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Cali (CLO)

Feb 16, 2026 - Feb 28, 2026

From

USD297

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Bogota (BOG)

Feb 25, 2026 - Mar 02, 2026

From

USD293

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Cartagena (CTG)

Mar 17, 2026 - Mar 24, 2026

From

USD293

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Rio de Janeiro (GIG)

Feb 26, 2026 - Mar 18, 2026

From

USD592

Viewed 1 day ago

Round trip

Economy

Chicago (ORD)to

Sao Paulo (GRU)

Apr 04, 2026 - Apr 19, 2026

From

USD441

Viewed 1 hour ago

Round trip

Economy

Chicago (ORD)to

Santa Cruz (VVI)

Apr 03, 2026 - Apr 22, 2026

From

USD610

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Chicago flights

From

Budget

USD

Chicago (ORD)to

Panama (PTY)

May 21, 2026 - May 25, 2026

Round trip

Economy

From

USD557

Viewed 1 day ago

Chicago (ORD)to

Guayaquil (GYE)

Mar 05, 2026 - Mar 06, 2026

Round trip

Economy

From

USD342

Viewed 1 day ago

Chicago (ORD)to

Lima (LIM)

Apr 03, 2026 - Apr 24, 2026

Round trip

Economy

From

USD497

Viewed 1 day ago

Chicago (ORD)to

Quito (UIO)

Mar 03, 2026 - Mar 17, 2026

Round trip

Economy

From

USD355

Viewed 4 hours ago

Chicago (ORD)to

San José (SJO)

Mar 01, 2026 - Mar 09, 2026

Round trip

Economy

From

USD303

Viewed 1 day ago

Chicago (ORD)to

Medellin (MDE)

Apr 25, 2026 - May 03, 2026

Round trip

Economy

From

USD300

Viewed 1 day ago

Flights from Chicago with Copa Airlines

When flying from Chicago, Copa Airlines is the best option. Copa airlines offers you a practical and simple way to enjoy your trip without worrying about the little things. Enter the site and manage your flight details, book hotels, and rent cars.

Leaving Chicago’s International Airport

Chicago O'Hare International Airport (ORD) is located 27 km northwest of the center of the city, where it is easily connected to the 24-hour blue line train. For more convenience, you can take a taxi or hire a private shuttle. We offer free Wi-Fi for the first 20 minutes and charging terminals for electronic devices, so you will always be connected. You can also entertain yourself while waiting for your flight by visiting the variety of shops, restaurants, and art exhibitions.

Flying from Chicago with Copa Airlines

Book your flight from Chicago with Copa Airlines and connect to a growing number of destinations across the continent, enjoying a comfortable, timely and safe journey.