What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD280*

1 Passenger

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Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Bogota (BOG)

Apr 22, 2026 - May 18, 2026

From

USD280

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Medellin (MDE)

Aug 11, 2026 - Aug 18, 2026

From

USD287

Viewed 11 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Jul 05, 2026 - Jul 10, 2026

From

USD296

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

May 20, 2026 - May 25, 2026

From

USD313

Viewed 17 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

May 05, 2026 - May 09, 2026

From

USD321

Viewed 16 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Mexico City (MEX)

Apr 03, 2026 - Apr 11, 2026

From

USD415

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

May 03, 2026 - May 13, 2026

From

USD530

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Apr 25, 2026 - May 02, 2026

From

USD552

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Caracas (CCS)

May 15, 2026 - May 22, 2026

From

USD652

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

May 27, 2026 - Jun 06, 2026

From

USD743

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

May 12, 2026 - May 19, 2026

From

USD778

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

May 07, 2026 - May 13, 2026

From

USD800

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Bogota (BOG)

May 24, 2026 - May 29, 2026

Round trip

Economy

From

USD280

Viewed 1 day ago

Santo Domingo (SDQ)to

Medellin (MDE)

Jul 16, 2026 - Jul 20, 2026

Round trip

Economy

From

USD287

Viewed 16 hours ago

Santo Domingo (SDQ)to

Lima (LIM)

Jul 23, 2026 - Jul 29, 2026

Round trip

Economy

From

USD313

Viewed 18 hours ago

Santo Domingo (SDQ)to

Panama (PTY)

Apr 25, 2026 - May 02, 2026

Round trip

Economy

From

USD552

Viewed 1 day ago

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Jun 02, 2026 - Jun 09, 2026

Round trip

Economy

From

USD778

Viewed 1 day ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Jun 08, 2026 - Jul 31, 2026

Round trip

Economy

From

USD800

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.