What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD 493*

1 Passenger

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Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Nov 09, 2026 - Nov 14, 2026

From

USD 285

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Oct 27, 2026 - Oct 29, 2026

From

USD 303

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Nov 05, 2026 - Nov 06, 2026

From

USD 307

Viewed 18 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

Nov 10, 2026 - Nov 14, 2026

From

USD 356

Viewed 22 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Jan 18, 2027 - Jan 23, 2027

From

USD 376

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Oct 15, 2026 - Oct 17, 2026

From

USD 493

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Caracas (CCS)

Nov 08, 2026 - Nov 11, 2026

From

USD 495

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

Nov 16, 2026 - Nov 23, 2026

From

USD 660

Viewed 1 hour ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Nov 08, 2026 - Nov 15, 2026

From

USD 663

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Mar 04, 2027 - Mar 15, 2027

From

USD 671

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Oct 27, 2026 - Nov 02, 2026

From

USD 761

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Rio de Janeiro (GIG)

Apr 11, 2027 - Apr 18, 2027

From

USD 1,089

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Nov 09, 2026 - Nov 14, 2026

Round trip

Economy

From

USD 285

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Jan 26, 2027 - Jan 26, 2027

Round trip

Economy

From

USD 303

Viewed 1 day ago

Santo Domingo (SDQ)to

Cartagena (CTG)

Nov 22, 2026 - Nov 22, 2026

Round trip

Economy

From

USD 307

Viewed 22 hours ago

Santo Domingo (SDQ)to

Lima (LIM)

Jan 18, 2027 - Jan 23, 2027

Round trip

Economy

From

USD 376

Viewed 1 day ago

Santo Domingo (SDQ)to

Panama (PTY)

Nov 16, 2026 - Nov 18, 2026

Round trip

Economy

From

USD 493

Viewed 1 day ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Nov 09, 2026 - Nov 14, 2026

Round trip

Economy

From

USD 828

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.