What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD265*

1 Passenger

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From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Managua (MGA)

Nov 11, 2025 - Nov 17, 2025

From

USD703

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Panama (PTY)

Oct 25, 2025 - Oct 30, 2025

From

USD522

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Medellin (MDE)

Oct 21, 2025 - Oct 26, 2025

From

USD265

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Caracas (CCS)

Oct 02, 2025 - Oct 02, 2025

From

USD532

Viewed 12 hours ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Oct 06, 2025 - Oct 12, 2025

From

USD338

Viewed 22 hours ago

Round trip
/
Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Oct 16, 2025 - Oct 20, 2025

From

USD492

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Oct 05, 2025 - Oct 17, 2025

From

USD268

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Oct 13, 2025 - Oct 20, 2025

From

USD680

Viewed 1 hour ago

Round trip
/
Economy

Santo Domingo (SDQ)to

San José (SJO)

Oct 20, 2025 - Oct 27, 2025

From

USD284

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Sep 29, 2025 - Oct 04, 2025

From

USD679

Viewed 1 hour ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Havana (HAV)

Oct 02, 2025 - Oct 06, 2025

From

USD331

Viewed 1 day ago

Round trip
/
Economy

Santo Domingo (SDQ)to

Cali (CLO)

Oct 08, 2025 - Oct 14, 2025

From

USD333

Viewed 2 hours ago

Round trip
/
Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to
Managua (MGA)
Nov 11, 2025 - Nov 17, 2025
Round trip
/
Economy

From
USD703*
Viewed 1 day ago

Santo Domingo (SDQ)to
Panama (PTY)
Oct 25, 2025 - Oct 30, 2025
Round trip
/
Economy

From
USD522*
Viewed 1 day ago

Santo Domingo (SDQ)to
Medellin (MDE)
Oct 22, 2025 - Oct 27, 2025
Round trip
/
Economy

From
USD265*
Viewed 1 day ago

Santo Domingo (SDQ)to
Caracas (CCS)
Mar 17, 2026 - Apr 13, 2026
Round trip
/
Economy

From
USD559*
Viewed 1 day ago

Santo Domingo (SDQ)to
Bogota (BOG)
Oct 22, 2025 - Oct 25, 2025
Round trip
/
Economy

From
USD338*
Viewed 1 day ago

Santo Domingo (SDQ)to
San Salvador (SAL)
Oct 26, 2025 - Oct 31, 2025
Round trip
/
Economy

From
USD492*
Viewed 14 hours ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.