What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD 507*

1 Passenger

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Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Jul 15, 2026 - Jul 15, 2026

From

USD 288

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Jul 07, 2026 - Jul 12, 2026

From

USD 293

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Oct 02, 2026 - Oct 09, 2026

From

USD 297

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

Aug 25, 2026 - Sep 01, 2026

From

USD 323

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Sep 29, 2026 - Oct 07, 2026

From

USD 354

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Quito (UIO)

Jul 21, 2026 - Jul 27, 2026

From

USD 503

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Jul 14, 2026 - Jul 20, 2026

From

USD 507

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Aug 02, 2026 - Aug 14, 2026

From

USD 517

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Caracas (CCS)

Jul 19, 2026 - Aug 12, 2026

From

USD 521

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

Oct 15, 2026 - Oct 23, 2026

From

USD 655

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Aug 07, 2026 - Aug 14, 2026

From

USD 662

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Sep 19, 2026 - Sep 30, 2026

From

USD 687

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Sep 22, 2026 - Sep 25, 2026

Round trip

Economy

From

USD 288

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Nov 19, 2026 - Nov 23, 2026

Round trip

Economy

From

USD 293

Viewed 1 day ago

Santo Domingo (SDQ)to

Cartagena (CTG)

Oct 02, 2026 - Oct 09, 2026

Round trip

Economy

From

USD 297

Viewed 1 day ago

Santo Domingo (SDQ)to

Lima (LIM)

Sep 29, 2026 - Oct 07, 2026

Round trip

Economy

From

USD 354

Viewed 1 day ago

Santo Domingo (SDQ)to

Panama (PTY)

Aug 04, 2026 - Aug 10, 2026

Round trip

Economy

From

USD 507

Viewed 1 day ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Aug 07, 2026 - Aug 14, 2026

Round trip

Economy

From

USD 662

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.