What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD 535*

1 Passenger

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Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Sep 18, 2026 - Sep 26, 2026

From

USD 298

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Sep 17, 2026 - Sep 22, 2026

From

USD 303

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Guatemala (GUA)

Sep 24, 2026 - Sep 28, 2026

From

USD 332

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

Oct 27, 2026 - Nov 07, 2026

From

USD 333

Viewed 49 minutes ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Dec 10, 2026 - Dec 17, 2026

From

USD 364

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Guayaquil (GYE)

Sep 15, 2026 - Oct 05, 2026

From

USD 402

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Mexico City (MEX)

Nov 04, 2026 - Nov 19, 2026

From

USD 464

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Sep 09, 2026 - Sep 18, 2026

From

USD 502

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Aug 31, 2026 - Sep 06, 2026

From

USD 535

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

Nov 17, 2026 - Nov 27, 2026

From

USD 637

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Sep 01, 2026 - Sep 18, 2026

From

USD 678

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Oct 21, 2026 - Oct 26, 2026

From

USD 707

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Nov 06, 2026 - Nov 09, 2026

Round trip

Economy

From

USD 298

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Sep 21, 2026 - Sep 28, 2026

Round trip

Economy

From

USD 303

Viewed 1 day ago

Santo Domingo (SDQ)to

San José (SJO)

Oct 27, 2026 - Nov 07, 2026

Round trip

Economy

From

USD 333

Viewed 49 minutes ago

Santo Domingo (SDQ)to

Lima (LIM)

Dec 10, 2026 - Dec 17, 2026

Round trip

Economy

From

USD 364

Viewed 1 day ago

Santo Domingo (SDQ)to

Panama (PTY)

Nov 13, 2026 - Nov 15, 2026

Round trip

Economy

From

USD 535

Viewed 1 day ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Sep 24, 2026 - Oct 08, 2026

Round trip

Economy

From

USD 707

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.