What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD257*

1 Passenger

Promo Code

From

Departure

Return

Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

May 03, 2026 - Jun 07, 2026

From

USD741

Viewed 22 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Mar 08, 2026 - Mar 15, 2026

From

USD548

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Medellin (MDE)

Apr 30, 2026 - May 08, 2026

From

USD287

Viewed 9 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Caracas (CCS)

Feb 17, 2026 - Mar 02, 2026

From

USD570

Viewed 8 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Mar 29, 2026 - Apr 03, 2026

From

USD273

Viewed 21 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Apr 21, 2026 - Apr 30, 2026

From

USD257

Viewed 10 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

May 06, 2026 - Jun 03, 2026

From

USD695

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Dec 02, 2026 - Dec 08, 2026

From

USD612

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Quito (UIO)

Feb 21, 2026 - Mar 02, 2026

From

USD469

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Mar 23, 2026 - Mar 26, 2026

From

USD730

Viewed 9 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Mexico City (MEX)

Feb 11, 2026 - Mar 16, 2026

From

USD390

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Jun 30, 2026 - Jul 07, 2026

From

USD406

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

May 03, 2026 - Jun 07, 2026

Round trip

Economy

From

USD741

Viewed 22 hours ago

Santo Domingo (SDQ)to

Panama (PTY)

Apr 03, 2026 - Apr 09, 2026

Round trip

Economy

From

USD548

Viewed 1 day ago

Santo Domingo (SDQ)to

Medellin (MDE)

Jul 01, 2026 - Jul 06, 2026

Round trip

Economy

From

USD287

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Apr 01, 2026 - Apr 06, 2026

Round trip

Economy

From

USD257

Viewed 1 day ago

Santo Domingo (SDQ)to

Caracas (CCS)

Apr 30, 2026 - May 11, 2026

Round trip

Economy

From

USD570

Viewed 1 day ago

Santo Domingo (SDQ)to

Cartagena (CTG)

Mar 29, 2026 - Apr 03, 2026

Round trip

Economy

From

USD273

Viewed 21 hours ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.