What is the best fare to fly from Santo Domingo?

The best fare to fly from Santo Domingo starts at **Flights.FromLowestPrice**. Fly with Copa Airlines.

Find Copa Airlines flights from Santo Domingo (SDQ) from USD 583*

1 Passenger

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Restrictions apply; please see Terms & Conditions.

Offers on flights from Santo Domingo

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Aug 16, 2026 - Aug 20, 2026

From

USD 288

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Bogota (BOG)

Jun 04, 2026 - Jun 07, 2026

From

USD 293

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Cartagena (CTG)

Jun 12, 2026 - Jun 19, 2026

From

USD 297

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Guatemala (GUA)

Oct 13, 2026 - Oct 19, 2026

From

USD 322

Viewed 12 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

San José (SJO)

Aug 18, 2026 - Sep 02, 2026

From

USD 323

Viewed 11 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Lima (LIM)

Jun 29, 2026 - Jul 07, 2026

From

USD 354

Viewed 17 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Mexico City (MEX)

May 13, 2026 - May 13, 2026

From

USD 415

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

San Salvador (SAL)

Jun 02, 2026 - Jun 10, 2026

From

USD 531

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Panama (PTY)

Oct 28, 2026 - Nov 03, 2026

From

USD 583

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Buenos Aires (EZE)

May 27, 2026 - Jun 06, 2026

From

USD 720

Viewed 23 hours ago

Round trip

Economy

Santo Domingo (SDQ)to

Sao Paulo (GRU)

Sep 22, 2026 - Sep 29, 2026

From

USD 815

Viewed 1 day ago

Round trip

Economy

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

May 12, 2026 - May 18, 2026

From

USD 836

Viewed 1 day ago

Round trip

Economy

*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.

Best prices on Santo Domingo flights

From

Budget

USD

Santo Domingo (SDQ)to

Medellin (MDE)

Jun 23, 2026 - Jun 30, 2026

Round trip

Economy

From

USD 288

Viewed 1 day ago

Santo Domingo (SDQ)to

Bogota (BOG)

Sep 29, 2026 - Oct 07, 2026

Round trip

Economy

From

USD 293

Viewed 1 day ago

Santo Domingo (SDQ)to

Lima (LIM)

Jun 29, 2026 - Jul 07, 2026

Round trip

Economy

From

USD 354

Viewed 17 hours ago

Santo Domingo (SDQ)to

San Salvador (SAL)

Jun 26, 2026 - Jun 29, 2026

Round trip

Economy

From

USD 531

Viewed 20 hours ago

Santo Domingo (SDQ)to

Panama (PTY)

Oct 28, 2026 - Nov 03, 2026

Round trip

Economy

From

USD 583

Viewed 1 day ago

Santo Domingo (SDQ)to

Santiago de Chile (SCL)

Aug 15, 2026 - Nov 15, 2026

Round trip

Economy

From

USD 836

Viewed 1 day ago

Flights from Santo Domingo with Copa Airlines

If you have to travel, book your flight from Santo Domingo with Copa Airlines and take advantage of our programs with extra benefits, like ConnectMiles – the loyalty program that we offer all our clients.

Departing from the International Airport Las Americas

Start your trip at the International Airport Las Americas (SDQ), which is just 45 minutes away from the capital city. This big airport offers you modern facilities that include information screens, Copa Club, VIP waiting rooms, playgrounds for children, shops, and restaurants. It also has Wi-Fi, so you stay connected while you wait for our flight. Get there on time by taxi or rent a car.

Fly from Santo Domingo to your next adventure in the company of Copa Airlines

Copa Airlines can take you to more than 70 destinations in the most important cities in America from the Hub of the Americas. We always offer you the kind service and punctuality that is typical on board of your flights form Santo Domingo.