Find Copa Airlines flights from Medellin (MDE) to Santo Domingo (SDQ) from USD280*
expand_more
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Restrictions apply; please see Terms & Conditions.
Best prices on Medellin to Santo Domingo flights
location_on
location_on
Best airfares from Medellin to Santo Domingo flights
flight_takeoff
flight_land
USD
From | To | Fare Type | Dates | Price |
|---|---|---|---|---|
| Medellin (MDE) | Santo Domingo (SDQ) | Round trip / Economy | Feb 09, 2026 - Feb 14, 2026 | From USD280 Viewed 5 hours ago |
| Medellin (MDE) | Santo Domingo (SDQ) | Round trip / Economy | Feb 08, 2026 - Feb 14, 2026 | From USD335 Viewed 5 hours ago |
| Medellin (MDE) | Santo Domingo (SDQ) | Round trip / Economy | Jan 05, 2026 - Jan 10, 2026 | From USD436 Viewed 1 hour ago |
| Medellin (MDE) | Santo Domingo (SDQ) | Round trip / Economy | Jan 02, 2026 - Jan 11, 2026 | From USD541 Viewed 1 hour ago |
| Medellin (MDE) | Santo Domingo (SDQ) | Round trip / Economy | Jan 17, 2026 - Jan 24, 2026 | From USD421 Viewed 1 day ago |
*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.
Our App
Download the Copa Airlines App now and buy tickets, manage your reservations, access to your ConnectMiles account and much more.
Subscribe and save!
Subscribe and be one of the first to know about our exclusive fares, promotions and last minute offers.
Subscribe