Find Copa Airlines flights from Medellin (MDE) to Guayaquil (GYE) from USD 368*
expand_more
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Restrictions apply; please see Terms & Conditions.
Best prices on Medellin to Guayaquil flights
location_on
location_on
Best airfares from Medellin to Guayaquil flights
flight_takeoff
flight_land
USD
From | To | Fare Type | Dates | Price |
|---|---|---|---|---|
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Nov 10, 2026 - Nov 17, 2026 | From USDÂ 368 Viewed 1 day ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Sep 21, 2026 - Sep 21, 2026 | From USDÂ 552 Viewed 1 day ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Sep 16, 2026 - Sep 18, 2026 | From USDÂ 368 Viewed 12 hours ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Sep 17, 2026 - Dec 16, 2026 | From USDÂ 580 Viewed 8 hours ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Nov 27, 2026 - Nov 29, 2026 | From USDÂ 413 Viewed 4 minutes ago |
*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.
Our App
Download the Copa Airlines App now and buy tickets, manage your reservations, access to your ConnectMiles account and much more.
Subscribe and save!
Subscribe and be one of the first to know about our exclusive fares, promotions and last minute offers.
Subscribe