Find Copa Airlines flights from Medellin (MDE) to Guayaquil (GYE) from USD 399*

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Best prices on Medellin to Guayaquil flights

Oct 2026
FromUSD 399*
Viewed 17 hours ago
Round trip/Economy
Nov 2026
FromUSD 399*
Viewed 15 hours ago
Round trip/Economy
Dec 2026
FromUSD 399*
Viewed 19 hours ago
Round trip/Economy
cmp-daily-histogram-bars-legend-min-price-aria-label USD 399
Displaying fares for October-2026
  • MDE–GYE, Oct 28, 2026 – Nov 04, 2026: From USD 399
    28

    Wed

    OCT

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    29

    Thu

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    30

    Fri

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    31

    Sat

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    01

    Sun

    NOV

  • MDE–GYE, Nov 02, 2026 – Nov 05, 2026: From USD 447
    02

    Mon

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    03

    Tue

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    04

    Wed

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    05

    Thu

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    06

    Fri

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    07

    Sat

  • MDE–GYE, Nov 08, 2026 – Nov 14, 2026: From USD 506
    08

    Sun

  • MDE–GYE, Nov 09, 2026 – Nov 14, 2026: From USD 442
    09

    Mon

  • MDE–GYE, Nov 10, 2026 – Nov 17, 2026: From USD 399
    10

    Tue

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    11

    Wed

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    12

    Thu

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    13

    Fri

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    14

    Sat

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    15

    Sun

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    16

    Mon

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    17

    Tue

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    18

    Wed

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    19

    Thu

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    20

    Fri

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    21

    Sat

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    22

    Sun

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    23

    Mon

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    24

    Tue

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    25

    Wed

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    26

    Thu

  • MDE–GYE: cmp-view-offers-disclaimer. Check availability
    27

    Fri

    • FromUSD 399-USD 506

    *Restrictions apply; please see Terms & Conditions.

    Round-trip fares from Medellin to Guayaquil

    USD
    Round-trip fares from Medellin to Guayaquil
    From
    To
    Fare Type
    Dates
    Price
    Medellin (MDE)Guayaquil (GYE)Round trip
    /
    Economy    		Dec 19, 2026 - Jan 26, 2027

    From

    USD 399

    Viewed 19 hours ago

    Medellin (MDE)Guayaquil (GYE)Round trip
    /
    Economy    		Oct 28, 2026 - Nov 04, 2026

    From

    USD 399

    Viewed 17 hours ago

    Medellin (MDE)Guayaquil (GYE)Round trip
    /
    Economy    		Nov 10, 2026 - Nov 17, 2026

    From

    USD 399

    Viewed 15 hours ago

    Medellin (MDE)Guayaquil (GYE)Round trip
    /
    Economy    		Dec 21, 2026 - Jan 25, 2027

    From

    USD 425

    Viewed 19 hours ago

    Medellin (MDE)Guayaquil (GYE)Round trip
    /
    Economy    		Dec 21, 2026 - Jan 26, 2027

    From

    USD 425

    Viewed 19 hours ago

    *Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
    *Restrictions apply; please see Terms & Conditions.

    Destination facts

    Destination airports
    • José Joaquín de Olmedo International Airport (GYE)
    Copa Airlines hub

    Hub of the Americas® in Panama

    Destination FAQs

    Which country or territory is the destination on this page in?

    Destination country or territory: Ecuador.

    How do I identify the arrival airport?

    Check the name and code of the arrival airport in your selected itinerary.

    Where is the Hub of the Americas®?

    Copa Airlines’ Hub of the Americas® is in Panama.

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