Find Copa Airlines flights from Medellin (MDE) to Guayaquil (GYE) from USD260*
expand_more
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Restrictions apply; please see Terms & Conditions.
Best prices on Medellin to Guayaquil flights
location_on
location_on
Best airfares from Medellin to Guayaquil flights
flight_takeoff
flight_land
USD
From | To | Fare Type | Dates | Price |
|---|---|---|---|---|
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Feb 12, 2026 - Feb 16, 2026 | From USD260 Viewed 14 hours ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jan 23, 2026 - Jan 25, 2026 | From USD296 Viewed 11 hours ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jan 23, 2026 - Jan 28, 2026 | From USD297 Viewed 1 day ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jan 16, 2026 - Jan 26, 2026 | From USD297 Viewed 1 day ago |
| Medellin (MDE) | Guayaquil (GYE) | Round trip / Economy | Jan 29, 2026 - Jan 29, 2026 | From USD297 Viewed 1 day ago |
*Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
*Restrictions apply; please see Terms & Conditions.
Our App
Download the Copa Airlines App now and buy tickets, manage your reservations, access to your ConnectMiles account and much more.
Subscribe and save!
Subscribe and be one of the first to know about our exclusive fares, promotions and last minute offers.
Subscribe