Find Copa Airlines flights from Santiago de los Caballeros (STI) to Medellin (MDE) from USD 358*

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Best prices on Santiago de los Caballeros to Medellin flights

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Oct 2026
No results available
Nov 2026
FromUSD 358*
Viewed 5 hours ago
Round trip/Economy
Dec 2026
FromUSD 457*
Viewed 1 day ago
Round trip/Economy
cmp-daily-histogram-bars-legend-min-price-aria-label USD 358
Displaying fares for October-2026
  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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    OCT

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    NOV

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  • STI–MDE, Nov 04, 2026 – Nov 07, 2026: From USD 358
    04

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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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  • STI–MDE, Nov 09, 2026 – Nov 14, 2026: From USD 585
    09

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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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  • STI–MDE, Nov 11, 2026 – Nov 16, 2026: From USD 612
    11

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  • STI–MDE, Nov 12, 2026 – Nov 16, 2026: From USD 409
    12

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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
    13

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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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  • STI–MDE: cmp-view-offers-disclaimer. Check availability
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    • FromUSD 358-USD 612

    *Restrictions apply; please see Terms & Conditions.

    Round-trip fares from Santiago de los Caballeros to Medellin

    USD
    Round-trip fares from Santiago de los Caballeros to Medellin
    From
    To
    Fare Type
    Dates
    Price
    Santiago de los Caballeros (STI)Medellin (MDE)Round trip
    /
    Economy    		Nov 04, 2026 - Nov 07, 2026

    From

    USD 358

    Viewed 5 hours ago

    Santiago de los Caballeros (STI)Medellin (MDE)Round trip
    /
    Economy    		Nov 30, 2026 - Dec 07, 2026

    From

    USD 409

    Viewed 1 day ago

    Santiago de los Caballeros (STI)Medellin (MDE)Round trip
    /
    Economy    		Dec 03, 2026 - Dec 07, 2026

    From

    USD 457

    Viewed 1 day ago

    Santiago de los Caballeros (STI)Medellin (MDE)Round trip
    /
    Economy    		Nov 12, 2026 - Nov 16, 2026

    From

    USD 409

    Viewed 1 day ago

    Santiago de los Caballeros (STI)Medellin (MDE)Round trip
    /
    Economy    		Apr 02, 2027 - Apr 05, 2027

    From

    USD 436

    Viewed 1 day ago

    *Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply.
    *Restrictions apply; please see Terms & Conditions.

    Destination facts

    Destination airports
    • José María Córdova International Airport (MDE)
    Copa Airlines hub

    Hub of the Americas® in Panama

    Destination FAQs

    Which country or territory is the destination on this page in?

    Destination country or territory: Colombia.

    How do I identify the arrival airport?

    Check the name and code of the arrival airport in your selected itinerary.

    Where is the Hub of the Americas®?

    Copa Airlines’ Hub of the Americas® is in Panama.

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